Companion website for the book 'Changing Connectomes'

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Chapter 9: Module Formation

Parallel and serial growth

Code for parallel and serial axonal outgrowth, as described in [1], is available here.

Multiple time windows

Code for connection establishment following time windows, as described in [2], is available here. The generated networks are available here. All scripts and functions are described in detail in the documentation.

Using multiple time windows, leading to heterochronous and spatially ordered neurodevelopmental gradients, Goulas and colleagues were able to reproduce brain connectivity patterns as observed in fly and human connectomes [3]. Their code is available here.

References

[1] Lim, S., and M. Kaiser. 2015. Developmental time windows for axon growth influence neuronal network topology. Biol Cybern 109 (2): 275-86

[2] Nisbach, F., and M. Kaiser. 2007. Developmental time windows for spatial growth generate multiple-cluster small-world networks. European Physical Journal B 58 (2): 185-191

[3] Goulas, A., R. F. Betzel, and C. C. Hilgetag. 2019. Spatiotemporal ontogeny of brain wiring. Science Advances 5 (6): eaav9694

  • https://connectomelab.github.io/changingconnectomes/
  • https://mitpress.mit.edu/books/changing-connectomes